Duhuo Jisheng Wan
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What is Duhuo Jisheng Wan?
Duhuo Jisheng Wan is a traditional 15-herb formulation labeled for cold-related lower-back and knee pain and difficulty bending or straightening the joints. Its traditional functions are to nourish the blood, relax the sinews, expel wind, and dispel dampness.
Recommended Use
For cold-related lower-back and knee pain, with difficulty bending or straightening the joints.
Product Information
| Chinese name | 独活寄生丸 |
|---|---|
| Alternative Name | Duhuo Jisheng Wan/ Duhuo Jisheng Pill |
| Brand | 立效 |
| Manufacturer | 山西华康药业股份有限公司 |
| China Drug Approval No. | Z20043469 |
| Drug Standard | YBZ07312004 |
| Dosage form | pill |
| Strength | 6 g per sachet |
| Individual package | 6 g × 6 sachets |
| GTIN | 6922628488852 |
| Prescription Status in China | Prescription medicine. |
Ingredients
Duhuo Jisheng Wan is made from 15 herbs: Pubescent angelica root (Du Huo), Chinese Taxillus twig (Sang Ji Sheng), Rehmannia root (Di Huang), Achyranthes root (Niu Xi), Asarum (Xi Xin), Chinese gentian root (Qin Jiao), Poria (Fu Ling), Cinnamon bark (Rou Gui), Saposhnikovia root (Fang Feng), Sichuan lovage rhizome (Chuan Xiong), Pilose Asiabell Root (Dang Shen), Licorice root (Gan Cao), Chinese angelica root (Dang Gui), White peony root (Bai Shao), and Eucommia bark (Du Zhong).
Benefits & Uses
Benefits & Common Uses
Duhuo Jisheng Wan is commonly used for symptoms such as:
- Lower back pain
- Knee pain
- Joint pain and stiffness
- Limited joint mobility
- Cold-related musculoskeletal discomfort
How It Works
Modern research has investigated bioactive constituents in several ingredients in the Duhuo Jisheng Wan formula, providing insight into biological activities that may help explain aspects of its traditional use.
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Pubescent angelica root (Du Huo)
Modern research on pubescent angelica root (Du Huo) has examined coumarins and volatile constituents, with experimental studies exploring inflammatory signaling, pain-related pathways, and antioxidant activity.
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Chinese Taxillus twig (Sang Ji Sheng)
Chinese Taxillus twig (Sang Ji Sheng) contains flavonoids such as quercetin and quercitrin, with modern preclinical studies investigating bone remodeling, oxidative processes, and inflammatory mediator production in species-specific extracts.
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Rehmannia root (Di Huang)
Key bioactive constituents of Rehmannia root (Di Huang), including catalpol, rehmannioside D, verbascoside, and stachyose, have been investigated for anti-inflammatory, antioxidant, glucose-regulatory, and tissue-protective biological activities.
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Achyranthes root (Niu Xi)
Achyranthes root (Niu Xi; Achyranthis Radix) refers to Achyranthes bidentata root; studies of defined extracts report bone and kidney effects in animal models, but results do not establish treatment efficacy or safety in people.
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Asarum (Xi Xin)
Asarum roots and rhizomes contain volatile phenylpropanoids including methyl eugenol and safrole, alongside lignans, with modern research investigating inflammatory signaling and pain responses while examining preparation-dependent toxicity and aristolochic acid exposure.
Traditional Functions & Uses
养血舒筋，祛风除湿
Nourish the blood, relax the sinews, expel wind, and dispel dampness.
- Wind-Cold-Damp Bi pattern
- Cold pain in the lower back and knees
- Difficulty bending or straightening the joints
Duhuo Jisheng Wan is classified as a prescription medicine in China. This Learn information is for educational purposes only. Always consult a healthcare provider before starting TCM treatments.
Safety
Precautions
The reviewed product reference does not specify adverse reactions or contraindications. Ask a clinician or pharmacist about possible medicine interactions and follow the package insert.
Evidence
Evidence at a Glance
One small randomized trial compared a locally prepared modified pill formula with diclofenac; a review found mostly high-risk-of-bias decoction studies, and a knee-osteoarthritis guideline gives a weak recommendation.
Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial
Both groups improved on several measures by week four; diclofenac showed faster change on some outcomes. The tested preparation was a locally prepared recipe with a reduced Xixin proportion.
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Population: Adults with symptomatic knee osteoarthritis
Indication: Knee osteoarthritis
Intervention: Locally prepared Duhuo Jisheng Wan recipe; Xixin proportion reduced from the source recipe
Comparison: Diclofenac in a double-dummy design
Sample size: 200 randomized; 94 per group completed
Duration: 4 weeks
Reported findings
Both groups improved on several measures by week four; diclofenac showed faster change on some outcomes. The tested preparation was a locally prepared recipe with a reduced Xixin proportion.
Interpretation
Formula-level clinical evidence with uncertain equivalence to the current product.
Limitations
Single short trial; locally prepared modified recipe; 94 of 100 participants per arm completed follow-up.
Teekachunhatean S, et al. Chinese herbal recipe versus diclofenac in symptomatic treatment of osteoarthritis of the knee: a randomized controlled trial. BMC Complement Altern Med. 2004;4:19. doi:10.1186/1472-6882-4-19
Study type: Randomized Controlled Trial
Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials
Across 12 trials, most evidence concerned decoctions; the authors judged the evidence at high risk of bias and effectiveness and safety uncertain.
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Population: Adults with knee osteoarthritis across 12 included trials
Indication: Knee osteoarthritis
Intervention: Duhuo Jisheng decoction or pill, alone or combined with conventional care
Comparison: No intervention, placebo, conventional treatment, or combination comparators
Sample size: 12 trials; 982 participants
Duration: 3 to 12 weeks across trials
Reported findings
Across 12 trials, most evidence concerned decoctions; the authors judged the evidence at high risk of bias and effectiveness and safety uncertain.
Interpretation
The review supports cautious formula-level context, not a product-specific efficacy conclusion.
Limitations
Only one included trial used a pill; formulation and combination interventions varied and safety information was limited.
Zhang W, et al. Evidence of Chinese herbal medicine Duhuo Jisheng decoction for knee osteoarthritis: a systematic review of randomised clinical trials. BMJ Open. 2016;6:e008973. doi:10.1136/bmjopen-2015-008973
Study type: Systematic Review
中成药治疗膝骨关节炎临床应用指南（2020年）
The guideline gives a weak recommendation for Duhuo Jisheng Wan/decoction in remission-stage knee osteoarthritis; supporting evidence was limited.
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Population: Patients with knee osteoarthritis considered by the guideline
Indication: Remission-stage knee osteoarthritis
Intervention: Duhuo Jisheng Wan/decoction as described in the guideline
Comparison: Guideline recommendation synthesis; no single comparator
Sample size: Evidence recommendations synthesized from clinical studies
Duration: Not applicable
Reported findings
The guideline gives a weak recommendation for Duhuo Jisheng Wan/decoction in remission-stage knee osteoarthritis; supporting evidence was limited.
Interpretation
Guideline-level formula evidence with low certainty and no verified identity to the current product.
Limitations
Recommendation strength is weak; evidence quality is limited and the guideline synthesizes formula-level studies rather than testing one retail formulation.
中成药治疗膝骨关节炎临床应用指南（2020年）. 2021. doi:10.7661/j.cjim.20210225.104
Study type: Other
Verification
- Brand relationship confirmed
- Manufacturer legal name confirmed
- Approval number confirmed
- Current packaging matched
- Registration holder / manufacturer checked
- Authenticity method checked
- Label/source evidence recorded
Official Label Dosage
Take one 6 g sachet orally twice daily.
A purchase option’s quantity does not define how long you should take the medicine.