Wuzi Yanzong Wan
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What is Wuzi Yanzong Wan?
Wuzi Yanzong Wan is a 5-herb classic Traditional Chinese Medicine (TCM) formula traditionally used to support male reproductive health, fertility, and sexual function
Recommended Use
Traditionally used for impotence, infertility, involuntary ejaculation, premature ejaculation, low-back pain and dribbling after urination in the context of kidney deficiency with depleted essence.
Product Information
| Chinese name | 五子衍宗丸 |
|---|---|
| Alternative Name | Wuzi Yanzong Wan |
| Brand | Tong Ren Tang |
| Manufacturer | Beijing Tong Ren Tang Co., Ltd. |
| China Drug Approval No. | Z11020188 |
| Dosage form | pill |
| Strength | 10 g per 100 pills |
| Individual package | 60 g |
| GTIN | 6904579119023 |
| Prescription Status in China | Over-the-counter medicine. |
Ingredients
Wuzi Yanzong Wan is made from 5 herbs: Goji fruit (Gou Qi Zi), Chinese dodder seed (Tu Si Zi), Chinese raspberry fruit (Fu Pen Zi), Schisandra fruit (Wu Wei Zi), and Plantain seed (Che Qian Zi).
Benefits & Uses
Benefits & Common Uses
Wuzi Yanzong Wan is commonly used for male reproductive and urinary concerns, including:
- Male fertility support
- Male reproductive health
- Erectile difficulties
- Premature ejaculation
- Seminal emission
How It Works
Modern research has investigated bioactive constituents in several ingredients in the Wuzi Yanzong Wan formula, providing insight into biological activities that may help explain aspects of its traditional use.
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Goji fruit (Gou Qi Zi)
Key bioactive constituents of Goji fruit (Gou Qi Zi), including Lycium barbarum polysaccharides, zeaxanthin dipalmitate, and chlorogenic acid, have been investigated for antioxidant, glucose-regulatory, and retinal-pigment-related biological activities.
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Chinese dodder seed (Tu Si Zi)
Chinese dodder seed contains flavonoids such as hyperoside and kaempferol, lignans, and polysaccharides, with modern laboratory and animal studies investigating antioxidant mechanisms, immune markers, and bone cell activity without establishing corresponding human benefits.
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Chinese raspberry fruit (Fu Pen Zi)
Key bioactive constituents of Chinese raspberry fruit (Fu Pen Zi), including ellagic acid, kaempferol-3-O-rutinoside, and tiliroside, have been investigated for antioxidant, anti-inflammatory, and antiglycation biological activities.
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Schisandra fruit (Wu Wei Zi)
Schisandra fruit (Wu Wei Zi) contains lignans including schisandrin, gomisin A, and schisandrin B, investigated in cell and animal studies of chemically induced liver injury, antioxidant defenses, inflammatory signaling, and drug-metabolizing enzymes.
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Plantain seed (Che Qian Zi)
Salt-fried plantain seed (Yan Che Qian Zi) contains geniposidic acid, acteoside, and isoacteoside, while salt-processed seed extracts and selected constituents have been investigated for diuretic and antifibrotic activities in animal and laboratory studies, without establishing human clinical benefits.
Traditional Functions & Uses
补肾益精
Tonify the kidneys and replenish essence.
- Kidney deficiency with depleted essence presenting as impotence, infertility, involuntary ejaculation, premature ejaculation, low-back pain or post-urination dribbling.
In TCM, kidney essence describes a traditional concept linked with reproduction and development. Kidney deficiency with depleted essence is a traditional pattern; it does not identify a biomedical cause of infertility or urinary symptoms.
Wuzi Yanzong Wan is an over-the-counter (OTC) medicine in China. This Learn information is for educational purposes only. Always consult a healthcare provider before starting TCM treatments.
Safety
Contraindications
- Do not use if allergic to this medicine or any ingredient.
Precautions
Adverse reactions are not clearly established. Avoid use during a cold with fever. People with serious chronic illness, children, pregnant women and breastfeeding women should use it under medical guidance. Consult a clinician or pharmacist before combining it with other medicines. Seek medical advice if symptoms have not improved after four weeks. Avoid food that is difficult to digest, and moderate sexual activity during treatment. Do not use if the appearance has changed; keep out of reach of children.
Evidence
Evidence at a Glance
A review reported some better semen measures, but trial quality was limited. A placebo-controlled trial of a modified preparation found no therapeutic effect on semen parameters. These selected reports do not establish a testosterone benefit.
Effect of Wuzi Yanzong on semen quality in subfertile men: a double-blind, randomised, placebo-controlled trial (abridged secondary publication)
The modified Wuzi Yanzong preparation showed no therapeutic effect on sperm concentration, motility or total motile sperm compared with placebo at follow-up.
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Population: Men with suboptimal semen parameters; 253 recruited and 230 completed.
Indication: Male reproductive outcomes
Intervention: modified Wuzi Yanzong, a nine-ingredient preparation, twice daily
Comparison: Placebo
Sample size: 253 recruited; 230 completed
Duration: 3 months treatment; semen follow-up through 6 months
Reported findings
The modified Wuzi Yanzong preparation showed no therapeutic effect on sperm concentration, motility or total motile sperm compared with placebo at follow-up.
Interpretation
This trial tested a modified nine-ingredient preparation rather than the canonical five-ingredient formulation.
Limitations
The findings concern the modified preparation and the studied dose and population; they do not establish the effect of the five-ingredient formulation.
Effect of Wuzi Yanzong on semen quality in subfertile men: a double-blind, randomised, placebo-controlled trial (abridged secondary publication). Hong Kong Med J. 2025;31(Suppl 3):S40.
Authors: TC Li; RCC Wang; ZX Lin; GWS Kong; JPW Chung; HW Lok; DYL Chan
Journal: Hong Kong Medical Journal
Study type: Randomized Controlled Trial
PMID: 40605579
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials.
Across five trials, the review reported better sperm concentration and motility with Wuzi Yanzong Pill; sperm morphology did not differ significantly.
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Population: Five randomized controlled trials involving 960 participants with oligoasthenozoospermia.
Indication: Oligoasthenozoospermia / male reproductive outcomes
Intervention: Wuzi Yanzong Pill versus placebo or vitamin controls
Comparison: Placebo or vitamin controls
Sample size: Five RCTs; 960 participants
Duration: Varied
Reported findings
Across five trials, the review reported better sperm concentration and motility with Wuzi Yanzong Pill; sperm morphology did not differ significantly.
Interpretation
This review synthesizes formula-level trials, whose reported semen changes are not direct evidence for the current retail product.
Limitations
Trial quality was generally unsatisfactory and several outcomes showed substantial heterogeneity.
The Therapeutic Effects of a Traditional Chinese Medicine Formula Wuzi Yanzong Pill for the Treatment of Oligoasthenozoospermia: A Meta-Analysis of Randomized Controlled Trials.
Authors: Authors as indexed in PubMed
Journal: PubMed-indexed journal article
Year: 2018
Study type: Meta Analysis
PMID: 29576794
DOI: 10.1155/2018/2968025
Clinical observations on therapeutic effects of the modified Shengjing Zhongzi Tang in patients with asthenospermia and oligozoospermia.
Semen density and motility increased in both groups; Shengjing Zhongzi Tang had better semen measures than the Wuzi Yanzong Wan control arm.
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Population: Seventy patients with asthenospermia and oligozoospermia.
Indication: Oligoasthenozoospermia / male reproductive outcomes
Intervention: Wuzi Yanzong Wan in the control arm
Comparison: Shengjing Zhongzi Tang
Sample size: 70 participants
Duration: 3 months
Reported findings
Semen density and motility increased in both groups; Shengjing Zhongzi Tang had better semen measures than the Wuzi Yanzong Wan control arm.
Interpretation
Wuzi Yanzong Wan was the comparator arm in this active-comparator study.
Limitations
The study included 70 men and no placebo arm; it does not isolate an effect against no treatment.
Clinical observations on therapeutic effects of the modified Shengjing Zhongzi Tang in patients with asthenospermia and oligozoospermia.
Authors: Authors as indexed in PubMed
Journal: PubMed-indexed journal article
Year: 2011
Study type: Randomized Controlled Trial
PMID: 21977861
Clinical efficacy of Yougui capsules and Wuziyanzong pills on oligoasthenospermia.
Sperm viability and motility increased in both groups; Yougui Capsules had higher post-treatment values than the Wuziyanzong Pills control arm.
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Population: Eighty infertile men with oligoasthenospermia.
Indication: Oligoasthenozoospermia / male reproductive outcomes
Intervention: Wuziyanzong Pills in the control arm, 6 g twice daily
Comparison: Yougui Capsules, 1.68 g three times daily
Sample size: 80 participants
Duration: 12 weeks
Reported findings
Sperm viability and motility increased in both groups; Yougui Capsules had higher post-treatment values than the Wuziyanzong Pills control arm.
Interpretation
Wuziyanzong Pills served as the active comparator, with semen measurements assessed after twelve weeks.
Limitations
Only 80 participants were studied and there was no placebo arm; baseline changes cannot isolate the treatment effect.
Clinical efficacy of Yougui capsules and Wuziyanzong pills on oligoasthenospermia. Zhonghua Nan Ke Xue 2012;18(3):281-283. PMID 22474997.
Study type: Randomized Controlled Trial
PMID: 22474997
Verification
- Brand relationship confirmed
- Manufacturer legal name confirmed
- Approval number confirmed
- Current packaging matched
- Registration holder / manufacturer checked
- Authenticity method checked
- Label/source evidence recorded
Official Label Dosage
Take 6 g (60 pills) orally twice daily.
Additional Directions
Keep sealed.
Treatment Course
Seek medical advice if symptoms have not improved after four weeks.
A purchase option’s quantity does not define how long you should take the medicine.