Wenxin Keli

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Overview

What is Wenxin Keli?

Wenxin Keli is The First State-sanctioned TCM Herbs-based Antiarrhythmic Drug manufactured by Buchang Pharma since 1995. and it's the #1 best-selling TCM for Arrhythmia & Afib in China.

Product Information

Chinese name稳心颗粒
Alternative NameWenxin Keli(Sugar Free) /Wenxin Granule
BrandBuchang
ManufacturerSHANDONG BUCHANG PHARMACEUTICALS CO., LTD
China Drug Approval No.Z10950026
Drug StandardYBZ01032003
Dosage formgranule
StrengthEach 1 g is equivalent to 1.8 g of prepared medicinal materials.
Individual package5 g × 9 sachets
GTIN6927762130384
Prescription Status in ChinaPrescription medicine.

Ingredients

Wenxin Keli is made from 5 herbs: Pilose Asiabell Root (Dang Shen), Solomon’s seal rhizome (Huang Jing), Notoginseng (San Qi), Amber (Hu Po), and Nardostachys root (Gan Song).

Benefits & Uses

Benefits & Common Uses

Wenxin Keli is commonly used for:

  • Palpitations
  • Premature ventricular contractions (PVCs)
  • Premature atrial contractions (PACs)
  • Shortness of breath and fatigue associated with the indicated TCM pattern

How It Works

Modern research has investigated bioactive constituents in several ingredients in the Wenxin Keli formula, providing insight into biological activities that may help explain aspects of its traditional use.

  • Pilose Asiabell Root (Dang Shen)

    Key bioactive constituents of Pilose Asiabell Root (Dang Shen), including Codonopsis polysaccharides, lobetyolin, and tangshenoside I, have been investigated for immune-modulating, antioxidant, anti-inflammatory, and glucose-regulatory biological activities.

  • Solomon’s seal rhizome (Huang Jing)

    Key bioactive constituents of Solomon’s seal rhizome (Huang Jing), including polysaccharides and steroidal saponins, have been investigated for glucose-regulatory, lipid-modulating, and immunomodulatory biological activities in laboratory and animal studies of species-specific extracts and isolated fractions.

  • Notoginseng (San Qi)

    Key bioactive constituents of Notoginseng (San Qi), including notoginsenoside R1, ginsenoside Rg1, and ginsenoside Rb1, have been investigated for cardiovascular, antiplatelet, anti-inflammatory, and neuroprotective biological activities.

  • Amber (Hu Po)

    Amber is a fossilized or subfossil resin used as a medicinal material; studies of amber extracts have reported cell and mouse findings related to glucose handling and seizure-like behavior, but composition and provenance vary and human efficacy is unestablished.

  • Nardostachys root (Gan Song)

    Key bioactive constituents of Nardostachys root (Gan Song), including nardosinone and other sesquiterpenoids, have been investigated for neuroinflammatory mechanisms, neuroprotection, and possible blood-pressure effects in preclinical models and a small short-term human trial.

Traditional Functions & Uses

Replenish qi, nourish yin, promote blood movement, and disperse blood stasis.

  • Palpitations, shortness of breath, fatigue, chest tightness, and chest pain due to qi and yin deficiency with blood stasis obstructing the heart vessels; ventricular or atrial premature beats with this presentation.

A placebo-controlled trial of Wenxin Keli reported fewer premature ventricular contractions and related symptoms over four weeks. Other trials and reviews studied combination treatment with antiarrhythmic medicines, so those results cannot be attributed to the formula alone. A recent overview rated most evidence as low or very low certainty. These studies do not establish long-term benefit.

Understanding the TCM Perspective

In TCM, qi refers to functional energy and yin to nourishing, moistening aspects of the body. Their deficiency describes the traditional context for fatigue and shortness of breath. Blood stasis obstructing the heart vessels describes a traditional pattern associated with palpitations and chest discomfort; it is not a laboratory diagnosis or a synonym for a coronary blockage.

Wenxin Keli is classified as a prescription medicine in China. This Learn information is for educational purposes only. Always consult a healthcare provider before starting TCM treatments.

Safety

Adverse Reactions

  • Nausea
  • Vomiting
  • Abdominal discomfort
  • Bloating
  • Abdominal pain
  • Diarrhea
  • Dizziness
  • Headache
  • Rash
  • Itching
  • Chest tightness

Contraindications

  • Contraindicated in bradyarrhythmias.
  • Contraindicated in people allergic to the formulation or its ingredients.

Precautions

Use cautiously during pregnancy. Avoid tobacco, alcohol, and strong tea. Critically ill patients require comprehensive treatment. The formula contains Codonopsis root and should not be used with Veratrum (Li Lu).

Evidence

Evidence at a Glance

A placebo-controlled trial of Wenxin Keli reported fewer premature ventricular contractions and related symptoms over four weeks. Other trials and reviews studied combination treatment with antiarrhythmic medicines, so those results cannot be attributed to the formula alone. A recent overview rated most evidence as low or very low certainty. These studies do not establish long-term benefit.

  • The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial

    Design: Randomized double-blind placebo-controlled multicenter trial

    Year: 2015

    Sample size: 1200

    In a 1,200-participant trial, Wenxin Keli reduced premature ventricular contractions and related symptoms more than placebo over four weeks.

    Population: 1200 adults with frequent premature ventricular contractions without severe structural heart disease

    Indication: Frequent premature ventricular contractions

    Intervention: Wenxin Keli

    Comparison: Matched placebo

    Sample size: 1200

    Duration: 4 weeks

    Reported findings

    In a 1,200-participant trial, Wenxin Keli reduced premature ventricular contractions and related symptoms more than placebo over four weeks.

    Interpretation

    This is a clinical trial of the named canonical formula in a defined patient population.

    Limitations

    Four-week follow-up does not establish long-term benefit or safety, and the study does not establish equivalence to the current retail package.

    The Efficacy and Safety of Wenxin Keli in Patients with Frequent Premature Ventricular Contractions: A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Trial; doi:10.4103/0366-6999.166026; https://pmc.ncbi.nlm.nih.gov/articles/PMC4736861/

    Year: 2015

    Study type: randomized_controlled_trial

    DOI: 10.4103/0366-6999.166026

  • Metoprolol combined with Wenxin Keli for premature ventricular contractions in hypertensive heart disease

    Design: Randomized controlled trial of combination therapy

    Year: 2013

    Sample size: 75

    A 75-patient study reported a higher response rate with Wenxin Keli combined with metoprolol than with the metoprolol control; adverse-reaction rates did not differ significantly.

    Population: 75 patients with hypertensive heart disease and premature ventricular contractions

    Indication: Premature ventricular contractions in hypertensive heart disease

    Intervention: Wenxin Keli combined with metoprolol alongside antihypertensive treatment

    Comparison: Metoprolol alongside antihypertensive treatment

    Sample size: 75

    Duration: 1 year

    Reported findings

    A 75-patient study reported a higher response rate with Wenxin Keli combined with metoprolol than with the metoprolol control; adverse-reaction rates did not differ significantly.

    Interpretation

    This study evaluates adjunctive treatment; findings cannot be attributed to the formula alone.

    Limitations

    Small study and abstract-level methodological reporting limit certainty and assessment of bias.

    Metoprolol combined with Wenxin Keli for premature ventricular contractions in hypertensive heart disease; doi:10.3969/j.issn.1005-9202.2013.23.007; https://globe.wanfangdata.com.hk/app/knowledge/wfstyle/detail/Periodical?uid=zglnxzz201323007

    Study type: randomized_controlled_trial

    DOI: 10.3969/j.issn.1005-9202.2013.23.007

  • Efficacy and safety of Chinese herbal medicine Wenxin Keli for ventricular premature beats: A systematic review

    Design: Systematic review of randomized trials

    Year: 2016

    Ten trials suggested fewer premature beats and related symptoms versus placebo, and benefits when combined with amiodarone; comparisons with several other antiarrhythmic medicines showed no significant differences.

    Population: Patients with ventricular premature beats across 10 trials

    Indication: Ventricular premature beats

    Intervention: Wenxin Keli alone or combined with Western medicines

    Comparison: Placebo or conventional antiarrhythmic medicines

    Duration: Varied across included trials

    Reported findings

    Ten trials suggested fewer premature beats and related symptoms versus placebo, and benefits when combined with amiodarone; comparisons with several other antiarrhythmic medicines showed no significant differences.

    Interpretation

    This review contains both standalone-formula and combination-treatment comparisons.

    Limitations

    Small samples, risk of bias, and heterogeneous regimens limit confidence; pooled findings are not a single uniform treatment effect.

    Efficacy and safety of Chinese herbal medicine Wenxin Keli for ventricular premature beats: A systematic review; doi:10.1016/j.ctim.2016.10.007; https://pubmed.ncbi.nlm.nih.gov/27912945/

    Study type: systematic_review

    DOI: 10.1016/j.ctim.2016.10.007

  • Efficacy and safety of Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions: A systematic review and meta-analysis

    Design: Systematic review and meta-analysis of combination therapy

    Year: 2022

    Sample size: 954

    Eleven trials reported better symptom and electrocardiogram response with Wenxin Keli combined with metoprolol than with the metoprolol control, without a significant difference in adverse reactions.

    Population: 954 participants across 11 randomized trials

    Indication: Premature ventricular contractions

    Intervention: Wenxin Keli combined with metoprolol tartrate

    Comparison: Metoprolol tartrate alone

    Sample size: 954

    Duration: Mostly 4 weeks; one trial 16 weeks

    Reported findings

    Eleven trials reported better symptom and electrocardiogram response with Wenxin Keli combined with metoprolol than with the metoprolol control, without a significant difference in adverse reactions.

    Interpretation

    This is pooled adjunctive-treatment evidence, not an estimate of the formula used alone.

    Limitations

    Small trials, incomplete blinding and allocation reporting, and possible publication bias limit certainty.

    Efficacy and safety of Wenxin Keli combined with metoprolol tartrate in the treatment of premature ventricular contractions: A systematic review and meta-analysis; doi:10.3389/fcvm.2022.952657; https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2022.952657/full

    Study type: systematic_review

    DOI: 10.3389/fcvm.2022.952657

  • Efficacy and safety of Wenxin Keli for ventricular premature beat: An overview of systematic reviews and meta-analyses

    Design: Overview of systematic reviews and meta-analyses

    Year: 2026

    An overview found better Holter and symptom responses with adjunctive Wenxin Keli, but most outcomes had low or very low certainty and no significant adverse-effect difference.

    Population: 11 systematic reviews of ventricular premature beat treatment

    Indication: Ventricular premature beats

    Intervention: Wenxin Keli as adjunctive treatment with conventional medicines

    Comparison: Conventional medicines alone

    Duration: Varied across included reviews

    Reported findings

    An overview found better Holter and symptom responses with adjunctive Wenxin Keli, but most outcomes had low or very low certainty and no significant adverse-effect difference.

    Interpretation

    This overview summarizes reviews rather than adding an independent clinical trial; overlapping trials must not be counted as separate new participants.

    Limitations

    Most included reviews had critically low methodological quality, and the authors advised cautious interpretation.

    Efficacy and safety of Wenxin Keli for ventricular premature beat: An overview of systematic reviews and meta-analyses; doi:10.1097/MD.0000000000047265; https://pubmed.ncbi.nlm.nih.gov/41560113/

    Year: 2026

    Study type: systematic_review

    DOI: 10.1097/MD.0000000000047265

  • Wenxin Keli for Ventricular premature complexes with Heart failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

    Wenxin Keli for Ventricular premature complexes with Heart failure: A Systematic Review and Meta-Analysis of Randomized Clinical Trials; doi:10.1016/j.ctim.2017.06.006; https://pubmed.ncbi.nlm.nih.gov/28735831/

    Study type: systematic_review

    DOI: 10.1016/j.ctim.2017.06.006

  • The Dose-Effect Relationship of Wenxin Granules in the Treatment of Atrial Premature Beats

    The Dose-Effect Relationship of Wenxin Granules in the Treatment of Atrial Premature Beats; nct:NCT04163835; https://clinicaltrials.gov/study/NCT04163835

    Year: 2019

    Study type: clinical_trial

  • To Evaluate the Efficacy and Safety of Wenxin Keli in Treating Atrial Premature Beats

    To Evaluate the Efficacy and Safety of Wenxin Keli in Treating Atrial Premature Beats; nct:NCT02319603; https://clinicaltrials.gov/study/NCT02319603

    Year: 2014

    Study type: clinical_trial

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Official Label Dosage

Take one sachet orally three times daily, or as directed by your clinician.

A purchase option’s quantity does not define how long you should take the medicine.

Frequently Asked Questions About Wenxin Keli