Guizhi Fuling Capsule
#1 herbal alternative approach for secondary dysmenorrhea, irregular menstruation, pelvic masses caused by endometriosis and presentations associated with endometriosis.
- Brand
- Kangyuan
- China Approval No.
- Z10950005
- Dosage Form
- Capsule
- Individual package
- 0.31 g × 50 capsules
Price range: $106.00 through $198.00
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- Brand confirmedKangyuan
- Verified AuthenticityProduct authenticity checked
- Evidence & ResearchTraditional use + modern studies
- Authentic packaging matchedAs shown in photos
- Expert supportProduct guidance available
Overview
Medically reviewed by Dr. Xiaoyu Last reviewed: September 13, 2026
Guizhi Fuling Capsule is a Chinese patent medicine widely used in China for menstrual pain and other blood-stasis-pattern gynecological conditions. Its traditional function is to promote blood circulation, dispel blood stasis, and disperse masses.
| Chinese name | 桂枝茯苓胶囊 |
|---|---|
| Pinyin | Guizhi Fuling Jiaonang |
| Brand | Kangyuan |
| China Drug Approval No. | Z10950005 |
| Dosage form | capsule |
| Traditional function | Promotes blood circulation, dispels blood stasis, and disperses masses. |
| Strength | 0.31 g per capsule |
| Individual package | 0.31 g × 50 capsules |
| Recommended use | Used for blood-stasis-pattern presentations that may include menstrual pain, amenorrhea, gynecological masses, incomplete postpartum lochia, specified breast symptoms, or specified urinary symptoms associated with benign prostatic hyperplasia. |
| GTIN | 6934918700032 |
Main ingredients: Cinnamon twig, Poria, Moutan bark, Peach kernel, White peony root
Evidence at a Glance
A 240-participant, eight-center randomized double-blind placebo-controlled trial reported better menstrual-pain outcomes with Guizhi Fuling Capsule than placebo. A systematic review of 28 randomized trials also reported benefits when the capsule was added to low-dose mifepristone for uterine fibroids, although the included trials were generally poor quality and the findings apply to combination treatment.
Do not use during pregnancy. The product standard also instructs users to stop taking it during menstruation.
Uses
Common Uses
Guizhi Fuling Capsule is commonly used in China for health concerns such as:
- Painful or absent menstrual periods
- Pelvic or lower-abdominal pain and discomfort
- Symptoms associated with uterine fibroids, endometriosis, or ovarian cysts
- Breast pain or lumps associated with fibrocystic breast changes
- Certain urinary difficulties associated with an enlarged prostate
Traditional & Labeled Uses
活血，化瘀，消癥
Promotes blood circulation, dispels blood stasis, and disperses masses.
- Used for masses, amenorrhea, menstrual pain, or incomplete postpartum lochia associated with blood stasis obstructing the collaterals.
- Used for uterine fibroids, chronic pelvic inflammatory masses, endometriosis, or ovarian cysts when the stated traditional pattern is present.
- Used for cystic breast hyperplasia with breast pain, a breast mass, or chest and flank fullness when the stated traditional pattern is present.
- Used for benign prostatic hyperplasia with difficult, thin, or dribbling urination and lower-abdominal distension or pain when blood stasis obstructing the bladder is present.
Traditional and labeled uses describe the product-use context; they do not by themselves establish modern clinical effectiveness for every listed condition.
Understanding the TCM Perspective
“Blood stasis obstructing the collaterals” and “blood stasis obstructing the bladder” are Traditional Chinese Medicine patterns, not biomedical diagnoses.
Related TCM Patterns
Guizhi Fuling Capsule is classified as a prescription medicine in China. The information on this page is intended for product education and should not replace diagnosis or treatment advice from a qualified healthcare professional.
Safety
Pregnancy
Do not use Guizhi Fuling Capsule during pregnancy. Pregnancy is listed as a contraindication in the product standard.
Allergy
Do not use if you are allergic to the product or any ingredient.
Drug Interactions
The reviewed product standard does not provide specific interaction information. Ask the prescriber or pharmacist before combining this prescription medicine with other medicines or herbal products.
When to Seek Medical Advice
Contact the prescriber if upper-abdominal discomfort or pain persists or symptoms worsen. Seek urgent care for a serious allergic reaction, heavy or unusual bleeding, or another serious symptom.
Contraindications
- Do not use during pregnancy.
Reported Adverse Reactions
- Occasional upper-abdominal discomfort or dull pain has been reported; the product standard states that it may resolve after the medicine is stopped.
Evidence
Human Clinical Evidence
Guizhi Fuling Capsule for primary dysmenorrhea
Guizhi Fuling Capsule groups reported higher pain-relief response rates than placebo during treatment (68.42% and 67.57% versus 47.89%), with improvement persisting during follow-up.
Guizhi Fuling Capsule plus low-dose mifepristone for uterine fibroids
- Pooled fibroid volume, uterine volume, menstrual flow, hormone measures, and reported clinical response favored combined treatment.
- Adverse drug reactions were not significantly increased versus mifepristone alone (p=0.16).
Verification
PRODUCT IDENTITY
- Brand Name
- Kangyuan
- Chinese Name
- 康缘
- Manufacturer
- Jiangsu Kanion Pharmaceutical Co., Ltd.
- China drug approval number
- Z10950005
- Prescription status in China
- Prescription medicine.
These are Chinese product-registration details. They do not establish approval or availability in another country.
Verified by the AuthHerb Verification Team
- Brand relationship confirmed
- Manufacturer legal name confirmed
- Approval number confirmed
- Current packaging matched
- Registration holder / manufacturer checked
- Authenticity method checked
- Label/source evidence recorded
Ingredients
This product contains the following ingredients:
Official Label Dosage
Take 3 capsules orally 3 times daily after meals.
Follow the current package insert if its instructions differ.
Individual package: 0.31 g × 50 capsules
Missed Dose Information
No product-specific missed-dose instruction was identified.
Additional Directions
The product standard states an 8-week course for benign prostatic hyperplasia and a 12-week course for the other listed indications, or as directed by the prescriber.
The product standard instructs users to stop taking it during menstruation. Follow the current package insert and prescriber’s instructions.
A purchase option’s quantity does not define how long you should take the medicine.
Frequently Asked Questions About Guizhi Fuling Capsule
It is traditionally used for blood-stasis-pattern presentations that may include menstrual pain, amenorrhea, gynecological masses, incomplete postpartum lochia, and certain breast or urinary symptoms.
“Blood stasis” is a Traditional Chinese Medicine pattern, not a biomedical diagnosis.
A 240-participant placebo-controlled trial reported better menstrual-pain outcomes with Guizhi Fuling Capsule. A review of 28 trials also reported benefits when it was added to low-dose mifepristone for uterine fibroids, but the included trials were generally poor quality.
Take 3 capsules orally 3 times daily after meals, following the current package insert and prescriber’s instructions.
No. Pregnancy is listed as a contraindication in the product standard.
Contact the prescriber if upper-abdominal discomfort or pain persists or symptoms worsen. Seek urgent care for a serious allergic reaction, heavy or unusual bleeding, or another serious symptom.
References
Selected Research
-
[1]Guizhi Fuling Capsule for primary dysmenorrhea
Population: 240 participants aged 18–30 with primary dysmenorrhea at eight centers.
Indication: Primary dysmenorrhea
Intervention: High-dose or low-dose Guizhi Fuling Capsule.
Comparison: Placebo; 80 participants per group.
Sample size: 240 randomized
Duration: 3 menstrual cycles of treatment plus 3 cycles of follow-up
Reported findings
Guizhi Fuling Capsule groups reported higher pain-relief response rates than placebo during treatment (68.42% and 67.57% versus 47.89%), with improvement persisting during follow-up.
Interpretation
This trial provides direct human evidence that Guizhi Fuling Capsule improved menstrual-pain outcomes in the studied population.
Limitations
The study was manufacturer-affiliated, and the abstract does not report the exact high- and low-dose regimens or enough detail to assess every risk-of-bias domain.
Liu YJ, Xiao W, Wang ZZ, et al. Effects and safety of varying doses of Guizhi Fuling Capsule in patients with primary dysmenorrhea: a multicenter, randomized, double-blind, placebo-controlled clinical study. China Journal of Chinese Materia Medica. 2013;38(12):2019–2022. DOI: 10.4268/cjcmm20131235. PMID: 24066604.
Full title: Effects and safety of varying doses of Guizhi Fuling Capsule in primary dysmenorrhea
Authors: Yu-Jie Liu; Wei Xiao; Zhen-Zhong Wang; Bin-Jiang Zhao; Zhong-Ming Zhou; Hui-Zhong Jiang; Zhe Jin; Shao-Bin Wei; Zhe Wang; Dong-Mei Wang; Qin-Hua Xia; Jie Lin; Qi Wang
Journal: Zhongguo Zhong Yao Za Zhi
Study type: randomized_controlled_trial
PMID: 24066604
-
[2]Guizhi Fuling Capsule plus low-dose mifepristone for uterine fibroids
Population: 2,813 participants with uterine fibroids across 28 randomized trials.
Indication: Uterine fibroids
Intervention: Guizhi Fuling Capsule plus low-dose mifepristone.
Comparison: Low-dose mifepristone alone.
Sample size: 2,813 participants in 28 trials
Duration: Varied across included trials
Reported findings
- Pooled fibroid volume, uterine volume, menstrual flow, hormone measures, and reported clinical response favored combined treatment.
- Adverse drug reactions were not significantly increased versus mifepristone alone (p=0.16).
Interpretation
This review adds clinically relevant evidence for Guizhi Fuling Capsule as an add-on treatment for uterine fibroids.
Limitations
Evidence quality ranged from very low to moderate, the included trials were generally poor quality, and the findings concern combination treatment rather than the capsule alone.
Lei Y, Yang L, Yang H, et al. The efficacy and safety of Chinese herbal medicine Guizhi Fuling Capsule combined with low-dose mifepristone in the treatment of uterine fibroids: a systematic review and meta-analysis of 28 randomized controlled trials. BMC Complementary Medicine and Therapies. 2023;23:54. DOI: 10.1186/s12906-023-03842-y. PMID: 36803997.
Full title: Guizhi Fuling Capsule plus low-dose mifepristone for uterine fibroids: systematic review and meta-analysis
Authors: Yiming Lei; Lili Yang; Honglian Yang; Min Li; Li Ou; Yang Bai; Taiwei Dong; Feng Gao; Peifeng Wei
Study type: meta_analysis
PMID: 36803997
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